{"product_id":"milprazon-adult-cat-dewormer-per-tablet-for-4-8kg-48-tablet","title":"Milprazon adult cat dewormer per tablet for 4-8kg (48 tablet)","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eMilprazon 是一種針對貓和小貓的廣譜驅蟲治療。\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e這種肉味的薄膜包衣驅蟲藥片對各種腸道蠕蟲有效，包括蛔蟲、鉤蟲和絛蟲，包括跳蚤絛蟲和狐絛蟲。\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e米爾倍黴素肟和吡喹酮是兩種活性成分，共同防禦這些蠕蟲的幼蟲和成蟲階段。此外，它可以每月給藥以預防心絲蟲病。\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e用於貓和小貓的 Milprazon 口服驅蟲劑具有非常吸引人的風味，易於服用。\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e這些功能強大且風味獨特的驅蟲藥片可安全有效地用於至少 6 周大、體重 0.5 公斤（1.1 磅）或更多的小型貓科動物和小貓身上。\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch1\u003e\u003cbr\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003e2. QUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/strong\u003e\u003cbr\u003eEach film-coated tablet contains:\u003cbr\u003eActive substances:\u003cbr\u003eMilbemycin oxime 16 mg\u003cbr\u003ePraziquantel 40 mg\u003cbr\u003eExcipients:\u003cbr\u003eIron Oxide, yellow (E172) 0.03 mg\u003cbr\u003eIron Oxide, red (E172) 0.12 mg\u003cbr\u003eIron Oxide, black (E172) 0.05 mg\u003cbr\u003eTitanium dioxide (E171) 0.21 mg\u003cbr\u003eFor the full list of excipients, see section 6.1.\u003cbr\u003e\u003cstrong\u003e3. PHARMACEUTICAL FORM\u003c\/strong\u003e\u003cbr\u003eBrown, oval, biconvex film-coated tablets with score line on one side.\u003cbr\u003eThe tablets can be divided into halves.\u003cbr\u003e\u003cstrong\u003e4. CLINICAL PARTICULARS\u003c\/strong\u003e\u003cbr\u003e4.1 Target Species\u003cbr\u003eCats (weighing at least 2 kg).\u003cbr\u003e4.2 Indications for use, specifying the target species\u003cbr\u003eTreatment of mixed infections by immature and adult cestodes and nematodes of the\u003cbr\u003efollowing species:\u003cbr\u003e- Cestodes:\u003cbr\u003eDipylidium caninum\u003cbr\u003eTaenia spp.\u003cbr\u003eEchinococcus multilocularis\u003cbr\u003e- Nematodes:\u003cbr\u003eAncylostoma tubaeforme\u003cbr\u003eToxocara cati\u003cbr\u003eRevised: November 2024\u003cbr\u003eAN: 02133\/2023\u003cbr\u003ePage 2 of 7\u003cbr\u003ePrevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against\u003cbr\u003ecestodes is indicated.\u003cbr\u003e4.3 Contraindications\u003cbr\u003eDo not use in cats weighing less than 2 kg.\u003cbr\u003eDo not use in cases of hypersensitivity to the active substances or to any of the\u003cbr\u003eexcipients.\u003cbr\u003e4.4 Special warnings for each target species\u003cbr\u003eIt is recommended to treat all the animals living in the same household\u003cbr\u003econcomitantly.\u003cbr\u003eIn order to develop an effective worm control programme local epidemiological\u003cbr\u003einformation and the risk of exposure of the cat should be taken into account, and it is\u003cbr\u003erecommended to seek professional (e. g. veterinary) advice.\u003cbr\u003eWhen D. caninum infection is present, concomitant treatment against intermediate\u003cbr\u003ehosts, such as fleas and lice, should be considered to prevent re-infection.\u003cbr\u003eParasite resistance to any particular class of anthelmintic may develop following\u003cbr\u003efrequent, repeated use of an anthelmintic of that class.\u003cbr\u003e4.5 Special precautions for use\u003cbr\u003eSpecial precautions for use in animals\u003cbr\u003eNo studies have been performed with severely debilitated cats or individuals with\u003cbr\u003eseriously compromised kidney or liver function. The veterinary medicinal product is\u003cbr\u003enot recommended for such animals or only according to a benefit\/risk assessment by\u003cbr\u003ethe responsible veterinarian.\u003cbr\u003eEnsure cats and kittens weighing between 0.5 kg and =2 kg receive the appropriate\u003cbr\u003etablet strength (4 mg milbemycin oxime\/10 mg praziquantel) and the appropriate\u003cbr\u003edose (1\/2 or 1 tablet) for the corresponding weight band (1\/2 tablet for cats weighing\u003cbr\u003e0.5 to 1 kg; 1 tablet for cats weighing \u0026gt;1 to 2 kg).\u003cbr\u003eAs the tablets are flavoured, they should be stored in a safe place out of the reach of\u003cbr\u003eanimals.\u003cbr\u003eSpecial precautions to be taken by the person administering the veterinary medicinal\u003cbr\u003eproduct to animals\u003cbr\u003eAccidental ingestion of a tablet by a child may be harmful. In order to prevent children\u003cbr\u003efrom accessing the veterinary medicinal product, tablets should be administered and\u003cbr\u003estored out of sight and reach of children.\u003cbr\u003ePart tablets should be returned to the open blister pocket and inserted into the outer\u003cbr\u003ecarton.\u003cbr\u003eIn the event of accidental ingestion of one or more tablets, seek medical advice\u003cbr\u003eimmediately and show the package leaflet or the label to the physician.\u003cbr\u003eWash hands after use.\u003cbr\u003eSpecial precautions for the protection of the environment:\u003cbr\u003eNot applicable.\u003cbr\u003eRevised: November 2024\u003cbr\u003eAN: 02133\/2023\u003cbr\u003ePage 3 of 7\u003cbr\u003eOther precautions\u003cbr\u003eEchinococcosis represents a hazard for humans. As Echinococcosis is a notifiable\u003cbr\u003edisease to the World Organisation for Animal Health (WOAH), specific guidelines on\u003cbr\u003ethe treatment and follow-up, and on the safeguard of persons, need to be obtained\u003cbr\u003efrom the relevant competent authority (e.g. experts or institutes of parasitology).\u003cbr\u003e4.6 Adverse reactions (frequency and seriousness)\u003cbr\u003eCats:\u003cbr\u003eVery rare\u003cbr\u003e(\u0026lt;1 animal \/ 10,000 animals\u003cbr\u003etreated, including isolated\u003cbr\u003ereports):\u003cbr\u003eHypersensitivity reaction;\u003cbr\u003eSystemic disorders (e.g. lethargy)*;\u003cbr\u003eNeurological disorders (e.g. ataxia and muscle\u003cbr\u003etremors)*;\u003cbr\u003eDigestive tract disorders (e.g. emesis and\u003cbr\u003ediarrhoea)*.\u003cbr\u003e*Especially in young cats.\u003cbr\u003eReporting adverse events is important. It allows continuous safety monitoring of a\u003cbr\u003eveterinary medicinal product. Reports should be sent, preferably via a veterinarian, to\u003cbr\u003eeither the marketing authorisation holder or its local representative or the national\u003cbr\u003ecompetent authority via the national reporting system. See also section 16 of the\u003cbr\u003epackage leaflet for contact details.\u003cbr\u003e4.7 Use during pregnancy and lactation\u003cbr\u003ePregnancy and lactation:\u003cbr\u003eCan be used during pregnancy and lactation.\u003cbr\u003eFertility:\u003cbr\u003eCan be used in breeding animals.\u003cbr\u003e4.8 Interaction with other medicinal products and other forms of interaction\u003cbr\u003eNo interactions were observed when the recommended dose of the macrocyclic\u003cbr\u003elactone selamectin was administered during treatment with milbemycin oxime and\u003cbr\u003epraziquantel at the recommended dose. In the absence of further studies, caution\u003cbr\u003eshould be taken in the case of concurrent use of the veterinary medicinal product and\u003cbr\u003eother macrocyclic lactones. Also, no such studies have been performed with\u003cbr\u003ereproducing animals.\u003cbr\u003e4.9 Amounts to be administered and administration route\u003cbr\u003eOral use.\u003cbr\u003eTo ensure a correct dosage, body weight should be determined as accurately as\u003cbr\u003epossible.\u003cbr\u003eRevised: November 2024\u003cbr\u003eAN: 02133\/2023\u003cbr\u003ePage 4 of 7\u003cbr\u003eMinimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of\u003cbr\u003epraziquantel per kg are given orally as a single dose. The veterinary medicinal\u003cbr\u003eproduct should be administered with or after some food. Doing so ensures optimum\u003cbr\u003eprotection against heartworm disease.\u003cbr\u003eDepending on the bodyweight of the cat, the practical dosing is as follows:\u003cbr\u003eBody weight Film-coated tablets for\u003cbr\u003ecats\u003cbr\u003e2 - 4 kg ½ tablet\u003cbr\u003e\u0026gt; 4 - 8 kg 1 tablet\u003cbr\u003e\u0026gt; 8 - 12 kg 1½ tablets\u003cbr\u003eThe veterinary medicinal product can be inserted into a programme for prevention of\u003cbr\u003eheartworm disease if at the same time treatment against tapeworms is indicated. For\u003cbr\u003ethe prevention of heartworm disease: the veterinary medicinal product kills Dirofilaria\u003cbr\u003eimmitis larvae up to one month after their transmission by mosquitoes. For regular\u003cbr\u003eprevention of heartworm disease the use of a monosubstance is preferred.\u003cbr\u003e4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary\u003cbr\u003eIn case of overdose, in addition to adverse events observed at the recommended\u003cbr\u003edose (see 4.6), drooling may be observed. This sign will usually disappear\u003cbr\u003espontaneously within a day.\u003cbr\u003e4.11 Withdrawal period(s)\u003cbr\u003eNot applicable.\u003cbr\u003e\u003cstrong\u003e5. PHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003cbr\u003ePharmacotherapeutic group: Endectocides, Macrocyclic lactones, milbemycin,\u003cbr\u003ecombinations\u003cbr\u003eATCvet code: QP54AB51\u003cbr\u003e5.1 Pharmacodynamic properties\u003cbr\u003eMilbemycin oxime belongs to the group of macrocyclic lactones, isolated from the\u003cbr\u003efermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against\u003cbr\u003emites, against larval and adult stages of nematodes as well as against larvae of\u003cbr\u003eDirofilaria immitis.\u003cbr\u003eThe activity of milbemycin is related to its action on invertebrate neurotransmission:\u003cbr\u003eMilbemycin oxime, like avermectins and other milbemycins, increases nematode and\u003cbr\u003einsect membrane permeability to chloride ions via glutamate-gated chloride ion\u003cbr\u003echannels (related to vertebrate GABAA and glycine receptors). This leads to\u003cbr\u003ehyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of\u003cbr\u003ethe parasite.\u003cbr\u003ePraziquantel is an acylated pyrazino-isoquinoline derivative. Praziquantel is active\u003cbr\u003eagainst cestodes and trematodes. It modifies the permeability for calcium (influx of\u003cbr\u003eCa2+) in the membranes of the parasite inducing an imbalance in the membrane\u003cbr\u003eRevised: November 2024\u003cbr\u003eAN: 02133\/2023\u003cbr\u003ePage 5 of 7\u003cbr\u003estructures, leading to membrane depolarisation and almost instantaneous contraction\u003cbr\u003eof the musculature (tetany), rapid vacuolisation of the syncytial tegument and\u003cbr\u003esubsequent tegumental disintegration (blebbing), resulting in easier expulsion from\u003cbr\u003ethe gastrointestinal tract or death of the parasite.\u003cbr\u003e5.2 Pharmacokinetic particulars\u003cbr\u003eIn cats under fed condition, praziquantel reaches peak plasma concentrations within\u003cbr\u003e3 hours after oral administration.\u003cbr\u003eThe half life of elimination is around 2 hours.\u003cbr\u003eAfter oral administration in cats under fed condition, milbemycin oxime reaches peak\u003cbr\u003eplasma concentrations within 5 hours. The half life of elimination is around 43 hours\u003cbr\u003e(± 21 hours).\u003cbr\u003e\u003cstrong\u003e6. PHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003cbr\u003e6.1 List of excipients\u003cbr\u003eCore:\u003cbr\u003eCellulose, microcrystalline\u003cbr\u003eLactose monohydrate\u003cbr\u003ePovidone\u003cbr\u003eCroscarmellose sodium\u003cbr\u003eSilica, colloidal anhydrous\u003cbr\u003eMagnesium stearate\u003cbr\u003eCoat:\u003cbr\u003eHypromellose\u003cbr\u003eTalc\u003cbr\u003ePropylene glycol\u003cbr\u003eTitanium dioxide (E171)\u003cbr\u003eLiver Flavour\u003cbr\u003eYeast\u003cbr\u003eIron Oxide, yellow (E172)\u003cbr\u003eIron Oxide, red (E172)\u003cbr\u003eIron Oxide, black (E172)\u003cbr\u003e6.2 Major incompatibilities\u003cbr\u003eNot applicable.\u003cbr\u003e6.3 Shelf life\u003cbr\u003eShelf life of the veterinary medicinal product as packaged for sale: 3 years\u003cbr\u003eShelf life for halved tablets after first opening the immediate packaging: 6 months.\u003cbr\u003eRevised: November 2024\u003cbr\u003eAN: 02133\/2023\u003cbr\u003ePage 6 of 7\u003cbr\u003e6.4. Special precautions for storage\u003cbr\u003eStore in the original package in order to protect from moisture. This veterinary\u003cbr\u003emedicinal product does not require any special temperature storage conditions.\u003cbr\u003eHalved tablets should be stored below 25°C in the original blister and be used for the\u003cbr\u003enext administration.\u003cbr\u003eKeep the blister in the outer carton.\u003cbr\u003e6.5 Nature and composition of immediate packaging\u003cbr\u003eBlister packs consisting of cold formed OPA\/Al\/PVC foil and aluminium foil.\u003cbr\u003eCardboard box with 1 blister of 2 tablets.\u003cbr\u003eCardboard box with 1 blister of 4 tablets.\u003cbr\u003eCardboard box with 12 blisters, each blister contains 4 tablets (total 48 tablets).\u003cbr\u003eNot all pack sizes may be marketed.\u003cbr\u003e6.6 Special precautions for the disposal of unused veterinary medicinal\u003cbr\u003eproduct or waste materials derived from the use of such products\u003cbr\u003eMedicines should not be disposed of via wastewater.\u003cbr\u003eAny unused veterinary medicinal product or waste materials derived from such\u003cbr\u003eveterinary medicinal product should be disposed of in accordance with local\u003cbr\u003erequirements.\u003cbr\u003eThe veterinary medicinal product should not enter water courses as milbemycin\u003cbr\u003eoxime may be dangerous for fish and other aquatic organisms.\u003c\/p\u003e","brand":"Vetmacy","offers":[{"title":"Default Title","offer_id":47504132178159,"sku":null,"price":1999.0,"currency_code":"HKD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0687\/2462\/1551\/files\/Milprazon16mg-cat__74987.webp?v=1769075538","url":"https:\/\/vetmacy.com\/en\/products\/milprazon-adult-cat-dewormer-per-tablet-for-4-8kg-48-tablet","provider":"Vetmacy","version":"1.0","type":"link"}